Recombinant Antibody Production

Recombinant Antibody Production

We offer a panel of services to world-wide clients looking for recombinant monoclonal antibody production with our proprietary mammalian cell culture and recombinant expression platforms. Thanks to our high performing proprietary MetaCHO™ cell line, we rapidly produce high-quality, endotoxin-free recombinant antibodies at milligram-to-gram scale. We have experience manufacturing antibodies in a wide range of formats, including but not limited to chimeric antibody, antibody fragment, fc silent antibody, non-IgG Isotypes, bispecific antibody and afucosylated antibody. We also offer HEK293 productionas well as stable pool antibody production to meet different antibody expression needs.

Service Scope

Our Advantage

Pilot/large scale antibody production

  • Transient CHO/293
  • 30ml-100L scale
  • Chimeric antibody production
  • Non-IgG antibody production (IgM, IgE, IgA…)
  • High-quality products (SEC-HPLC >95%, endotoxin <1 EU/mg)

Timeline: 3-6 weeks

High throughput antibody production

  • Transient CHO
  • Mini & Midi Scale (24-DWP, 10ml, 30ml, 100ml, 200ml)
  • Automated production
  • Weekly capacity (2000 Abs)
  • Affordable price ($320/Ab, 1-3mg)


Timeline: 2-3 weeks

Antibody fragment production

  • Multiple antibody fragments (scFv, VHH, Fab, F (ab ‘) 2, etc.)
  • Versatile expression systems (E.coli, B.subtilis, Mammalian)
  • Fab / F (ab ‘) 2 generation by enzyme digestion

Timeline: 3-5 weeks

Stable pool antibody generation

  • Multiple grams antibody supply
  • Difficult-to-express antibody/protein production
  • High throughput stable pool selection




Timeline: 6-10 weeks

Afucosylated antibody production

  • Production by FUT8 knocked out cell line
  • By inhibiting fucosyltransferase
  • low- or non-fucosylated antibodies generation


Timeline: 3-5 weeks

Bispecific antibody production

  • Fragment-based formats (BiTE, BiKE, Diabodies, TandAb, DART, Fab-Fab…)
  • Symmetric formats ( KIH, DuoBody, ZW1, SEED…)
  • Asymmetric formats (DVD-Ig, FIT, IgG-VHH, IgG-ScFv, IgG-Fab)
  • QC (SDS-PAGE, SEC-HPLC, IEX-HPLC, LC-MS…)
Timeline: 3-6 weeks

Pilot/large scale antibody production

  • Transient CHO/293
  • 30ml-100L scale
  • Chimeric antibody production
  • Non-IgG antibody production (IgM, IgE, IgA…)
  • High-quality products (SEC-HPLC >95%, endotoxin <1 EU/mg)

Timeline: 3-6 weeks

High throughput antibody production

  • Transient CHO
  • Mini & Midi Scale (24-DWP, 10ml, 30ml, 100ml, 200ml)
  • Automated production
  • Weekly capacity (2000 Abs)
  • Affordable price ($320/Ab, 1-3mg)


Timeline: 2-3 weeks

Antibody fragment production

  • Multiple antibody fragments (scFv, VHH, Fab, F (ab ‘) 2, etc.)
  • Versatile expression systems (E.coli, B.subtilis, Mammalian)
  • Fab / F (ab ‘) 2 generation by enzyme digestion

Timeline: 3-5 weeks

Stable pool antibody generation

  • Multiple grams antibody supply
  • Difficult-to-express antibody/protein production
  • High throughput stable pool selection




Timeline: 6-10 weeks

Afucosylated antibody production

  • Production by FUT8 knocked out cell line
  • By inhibiting fucosyltransferase
  • low- or non-fucosylated antibodies generation


Timeline: 3-5 weeks

Bispecific antibody production

  • Fragment-based formats (BiTE, BiKE, Diabodies, TandAb, DART, Fab-Fab…)
  • Symmetric formats ( KIH, DuoBody, ZW1, SEED…)
  • Asymmetric formats (DVD-Ig, FIT, IgG-VHH, IgG-ScFv, IgG-Fab)
  • QC (SDS-PAGE, SEC-HPLC, IEX-HPLC, LC-MS…)
Timeline: 3-6 weeks

Proprietary Platform

MetaCHO_Timeline

Proprietary Platform

MetaCHO_Timeline

Interested in our Antibody Production Services?