Recombinant Antibody Production
Recombinant Antibody Production
We offer a panel of services to world-wide clients looking for recombinant monoclonal antibody production with our proprietary mammalian cell culture and recombinant expression platforms. Thanks to our high performing proprietary MetaCHO™ cell line, we rapidly produce high-quality, endotoxin-free recombinant antibodies at milligram-to-gram scale. We have experience manufacturing antibodies in a wide range of formats, including but not limited to chimeric antibody, antibody fragment, fc silent antibody, non-IgG Isotypes, bispecific antibody and afucosylated antibody. We also offer HEK293 productionas well as stable pool antibody production to meet different antibody expression needs.
Service Scope
- Pilot/large scale antibody production
- High throughput antibody production
- Stable pool antibody production
- Bispecific antibody production
- Antibody fragment production
- Afucosylated antibody production
Our Advantage
- Amounts guaranteed
- The market’s most competitive prices
- Short lead time (starting at 3 weeks)
- Vast choice of production systems (HEK or CHO)
Pilot/large scale antibody production
- Transient CHO/293
- 30ml-100L scale
- Chimeric antibody production
- Non-IgG antibody production (IgM, IgE, IgA…)
- High-quality products (SEC-HPLC >95%, endotoxin <1 EU/mg)
Timeline: 3-6 weeks
High throughput antibody production
- Transient CHO
- Mini & Midi Scale (24-DWP, 10ml, 30ml, 100ml, 200ml)
- Automated production
- Weekly capacity (2000 Abs)
- Affordable price ($320/Ab, 1-3mg)
Timeline: 2-3 weeks
Antibody fragment production
- Multiple antibody fragments (scFv, VHH, Fab, F (ab ‘) 2, etc.)
- Versatile expression systems (E.coli, B.subtilis, Mammalian)
- Fab / F (ab ‘) 2 generation by enzyme digestion
Timeline: 3-5 weeks
Stable pool antibody generation
- Multiple grams antibody supply
- Difficult-to-express antibody/protein production
- High throughput stable pool selection
Timeline: 6-10 weeks
Afucosylated antibody production
- Production by FUT8 knocked out cell line
- By inhibiting fucosyltransferase
- low- or non-fucosylated antibodies generation
Timeline: 3-5 weeks
Bispecific antibody production
- Fragment-based formats (BiTE, BiKE, Diabodies, TandAb, DART, Fab-Fab…)
- Symmetric formats ( KIH, DuoBody, ZW1, SEED…)
- Asymmetric formats (DVD-Ig, FIT, IgG-VHH, IgG-ScFv, IgG-Fab)
- QC (SDS-PAGE, SEC-HPLC, IEX-HPLC, LC-MS…)
Timeline: 3-6 weeks
Pilot/large scale antibody production
- Transient CHO/293
- 30ml-100L scale
- Chimeric antibody production
- Non-IgG antibody production (IgM, IgE, IgA…)
- High-quality products (SEC-HPLC >95%, endotoxin <1 EU/mg)
Timeline: 3-6 weeks
High throughput antibody production
- Transient CHO
- Mini & Midi Scale (24-DWP, 10ml, 30ml, 100ml, 200ml)
- Automated production
- Weekly capacity (2000 Abs)
- Affordable price ($320/Ab, 1-3mg)
Timeline: 2-3 weeks
Antibody fragment production
- Multiple antibody fragments (scFv, VHH, Fab, F (ab ‘) 2, etc.)
- Versatile expression systems (E.coli, B.subtilis, Mammalian)
- Fab / F (ab ‘) 2 generation by enzyme digestion
Timeline: 3-5 weeks
Stable pool antibody generation
- Multiple grams antibody supply
- Difficult-to-express antibody/protein production
- High throughput stable pool selection
Timeline: 6-10 weeks
Afucosylated antibody production
- Production by FUT8 knocked out cell line
- By inhibiting fucosyltransferase
- low- or non-fucosylated antibodies generation
Timeline: 3-5 weeks
Bispecific antibody production
- Fragment-based formats (BiTE, BiKE, Diabodies, TandAb, DART, Fab-Fab…)
- Symmetric formats ( KIH, DuoBody, ZW1, SEED…)
- Asymmetric formats (DVD-Ig, FIT, IgG-VHH, IgG-ScFv, IgG-Fab)
- QC (SDS-PAGE, SEC-HPLC, IEX-HPLC, LC-MS…)