In Vivo Pharmacology

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CDX tumor models

  • Subcutaneous/Systemic/Orthotopic/ Metastasis
  • 26 cancer types
  • Total 200+ models
  • Humanized immune system

Syngeneic tumor models

  • Subcutaneous/Orthotopic/Metastasis
  • 9 cancer types
  • huGene K/I mice experience
  • Combined immunotherapy

Auto-immune disease models

  • Respiratory disease
  • Rheumatoid Arthritis
  • Experimental autoimmune encephalomyelitis
  • Inflammatory Bowel Disease
  • Skin-related Disease
  • Systemic inflammation

CDX tumor model catalog

Models coming soon...

Systemic models

  • Leukemia(8): K562; KU812; MV-4-11; HEL 92.1.7; THP-1;  HL-60; MOLM-13; RS4;11

  • Lymphoma(4): Namalwa; Raji; Daudi;Raji-luc

  • Liver cancer(1): HepG2-Luc

  • Myeloma(2): NCI-H929; KMS34

  • Neuroblastoma(1): BE(2)-c

Orthotopic models

  • Breast cancer(3): MDA-MB-468, MDA-MB-231; BT-474

  • Glioblastoma(3): U87MG; U87-MG-Luc; AM-38-luc(subcutaneous)

  • Liver cancer(2): SK-HEP-1-Luc; Hep3B-Luc

  • Lung cancer(1): NCI-H1299-Luc

  • Multiple Myeloma(1): RPMI 8226

  • Ovarian cancer(1): OVCAR-3(nude rat)

  • Prostate cancer(2): PC-3-Luc, x1LNCaP-Luc

Metastasis models

  • Breast cancer(1): xBT-474-luc (via brain)

  • Lung cancer(1): NCI-H1299-Luc (via brain)

  • Melanoma(3): A375-Luc (via brain), A375-Luc (via carotid arterie), A375-Luc (via intracardia)

  • Prostate cancer(1): PC-3-Luc (by orthotopic)

Mouse Syngeneic Tumor Models

Auto-Immune Disease and Inflammation In Vivo Models

Auto-Immune Disease

  • Respiratory disease

  • OVA-induced asthma in mice

  • Bleomycin-induced lung fibrosis in mice

  • Rheumatoid Arthritis

  • Collagen induced arthritis in rats(CIA)

  • Adjuvant induced arthritis in rats (AIA)

  • Multiple Sclerosis (MS)

  • MOG-induced EAE in mice

  • PLP-induced EAE in mice

  • Adoptive transfer EAE model

Inflammation

  • Inflammatory Bowel Disease (IBD)

  • oDSS-induced IBD in mice(acute)

  • Skin-related Disease

  • IMQ induced psoriasis in mice

  • IL-23 induced hyperplasia in mice

  • Passive cutaneous anaphylaxis in mice (PCA)

  • DNFB/Oxa induced delayed type hypersensitivity in mice (DTH)

  • Systemic inflammation and others:

  • LPS-induced cytokine release in mice/rats

  • Systemic inflammation in mice (Con A)

  • Air pouch (mice, rats) 

Our Services

CDX tumor models

  • Subcutaneous/Systemic/Orthotopic/ Metastasis
  • 26 cancer types
  • Total 200+ models
  • Humanized immune system

Syngeneic tumor models

  • Subcutaneous/Orthotopic/Metastasis
  • 9 cancer types
  • huGene K/I mice experience
  • Combined immunotherapy

Auto-immune disease models

  • Respiratory disease
  • Rheumatoid Arthritis
  • Experimental autoimmune encephalomyelitis
  • Inflammatory Bowel Disease
  • Skin-related Disease
  • Systemic inflammation

CDX tumor model catalog

Models coming soon...

Systemic models

  • Leukemia(8): K562; KU812; MV-4-11; HEL 92.1.7; THP-1;  HL-60; MOLM-13; RS4;11

  • Lymphoma(4): Namalwa; Raji; Daudi;Raji-luc

  • Liver cancer(1): HepG2-Luc

  • Myeloma(2): NCI-H929; KMS34

  • Neuroblastoma(1): BE(2)-c

Orthotopic models

  • Breast cancer(3): MDA-MB-468, MDA-MB-231; BT-474

  • Glioblastoma(3): U87MG; U87-MG-Luc; AM-38-luc(subcutaneous)

  • Liver cancer(2): SK-HEP-1-Luc; Hep3B-Luc

  • Lung cancer(1): NCI-H1299-Luc

  • Multiple Myeloma(1): RPMI 8226

  • Ovarian cancer(1): OVCAR-3(nude rat)

  • Prostate cancer(2): PC-3-Luc, x1LNCaP-Luc

Metastasis models

  • Breast cancer(1): xBT-474-luc (via brain)

  • Lung cancer(1): NCI-H1299-Luc (via brain)

  • Melanoma(3): A375-Luc (via brain), A375-Luc (via carotid arterie), A375-Luc (via intracardia)

  • Prostate cancer(1): PC-3-Luc (by orthotopic)

Mouse Syngeneic Tumor Models

Auto-Immune Disease and Inflammation In Vivo Models

Auto-Immune Disease

  • Respiratory disease

  • OVA-induced asthma in mice

  • Bleomycin-induced lung fibrosis in mice

  • Rheumatoid Arthritis

  • Collagen induced arthritis in rats(CIA)

  • Adjuvant induced arthritis in rats (AIA)

  • Multiple Sclerosis (MS)

  • MOG-induced EAE in mice

  • PLP-induced EAE in mice

  • Adoptive transfer EAE model

Inflammation

  • Inflammatory Bowel Disease (IBD)

  • oDSS-induced IBD in mice(acute)

  • Skin-related Disease

  • IMQ induced psoriasis in mice

  • IL-23 induced hyperplasia in mice

  • Passive cutaneous anaphylaxis in mice (PCA)

  • DNFB/Oxa induced delayed type hypersensitivity in mice (DTH)

  • Systemic inflammation and others:

  • LPS-induced cytokine release in mice/rats

  • Systemic inflammation in mice (Con A)

  • Air pouch (mice, rats) 

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